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English Name：H-D-Phenylalanyl-L-pipecolyl-Larginine-p-nitroaniline

Another Name：S-2238

CAS Number：113711-77-6

Molecular Formula：H-D-Phe-Pip-Arg-pNA ? 2 HCl

Molecular Weight：625.55

Purity (HPLC)：> 99%

Absorption Coefficient：≤0.120 [L/(g·cm)]

Solubility：> 10 mg/mL in pure water

Storage Temperature：2-8℃

Packaging Specifications：25mg lyophilized powder (customizable in various quantities from mg to g levels)

Product Code：G04010237

S-2238 is a specific substrate for thrombin, with a structure designed to mimic the N-terminal region of the alpha chain of fibrinogen. Chemically modified to enhance stability and reactivity, it plays a critical role in detection. During testing, excess thrombin is added to the plasma sample, where antithrombin forms a 1:1 complex with thrombin. The remaining thrombin reacts with the chromogenic group p-nitroaniline of S-2238, producing coloration. The intensity of the color correlates positively with residual thrombin and negatively with antithrombin. By measuring absorbance changes through spectrophotometry, the activity can be precisely determined.